Differential requirements of MyD88 and TRIF pathways in TLR4-mediated immune responses in murine B cells

Highlights • MyD88 is sufficient for B cell responses induced by lipid A stimulation alone. • TRIF is required for lipid A plus IL-4-induced B cell division and CSR. • TRIF is required for lipid A plus IL-4-induced Aicda mRNA expression in B cells. • MyD88 may negatively regulate TLR4 plus IL-4R-med...

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Veröffentlicht in:	Immunology letters 2015-01, Vol.163 (1), p.22-31
Hauptverfasser:	Yanagibashi, Tsutomu, Nagai, Yoshinori, Watanabe, Yasuharu, Ikutani, Masashi, Hirai, Yoshikatsu, Takatsu, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - immunology Allergy and Immunology Animals Antibody Formation B-Lymphocytes - cytology B-Lymphocytes - immunology Immunoglobulin G - genetics Immunoglobulin G - immunology Mice Mice, Knockout Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - immunology Signal Transduction - genetics Signal Transduction - immunology Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology
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Zusammenfassung:	Highlights • MyD88 is sufficient for B cell responses induced by lipid A stimulation alone. • TRIF is required for lipid A plus IL-4-induced B cell division and CSR. • TRIF is required for lipid A plus IL-4-induced Aicda mRNA expression in B cells. • MyD88 may negatively regulate TLR4 plus IL-4R-mediated signaling in B cells. • IgG production to TNP-LPS immunization is largely dependent on TRIF signaling.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2014.11.012