Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule
Highlights • Immune responses of infants were assessed 1 month after the national UK schedule. • Infants could receive any of three meningococcal C conjugate vaccines at 3 and 4 months. • Responses were lower after CRM-conjugated followed by tetanus-conjugated MenC vaccine. • Conjugate vaccines with...
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| Veröffentlicht in: | Vaccine 2015-01, Vol.33 (5), p.648-655 |
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| creator | Ladhani, Shamez N Andrews, Nick J Waight, Pauline Hallis, Bassam Matheson, Mary England, Anna Findlow, Helen Bai, Xilian Borrow, Ray Burbidge, Polly Pearce, Emma Goldblatt, David Miller, Elizabeth |
| description | Highlights • Immune responses of infants were assessed 1 month after the national UK schedule. • Infants could receive any of three meningococcal C conjugate vaccines at 3 and 4 months. • Responses were lower after CRM-conjugated followed by tetanus-conjugated MenC vaccine. • Conjugate vaccines with different carrier proteins may not be interchangeable. • When possible children should receive conjugate vaccines with the same carrier protein. |
| doi_str_mv | 10.1016/j.vaccine.2014.12.018 |
| format | Article |
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J</creatorcontrib><creatorcontrib>Waight, Pauline</creatorcontrib><creatorcontrib>Hallis, Bassam</creatorcontrib><creatorcontrib>Matheson, Mary</creatorcontrib><creatorcontrib>England, Anna</creatorcontrib><creatorcontrib>Findlow, Helen</creatorcontrib><creatorcontrib>Bai, Xilian</creatorcontrib><creatorcontrib>Borrow, Ray</creatorcontrib><creatorcontrib>Burbidge, Polly</creatorcontrib><creatorcontrib>Pearce, Emma</creatorcontrib><creatorcontrib>Goldblatt, David</creatorcontrib><creatorcontrib>Miller, Elizabeth</creatorcontrib><title>Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • Immune responses of infants were assessed 1 month after the national UK schedule. • Infants could receive any of three meningococcal C conjugate vaccines at 3 and 4 months. • Responses were lower after CRM-conjugated followed by tetanus-conjugated MenC vaccine. • Conjugate vaccines with different carrier proteins may not be interchangeable. • When possible children should receive conjugate vaccines with the same carrier protein.</description><subject>Age</subject><subject>Allergy and Immunology</subject><subject>Antibodies, Bacterial - blood</subject><subject>Blood</subject><subject>Blood Bactericidal Activity</subject><subject>Carrier proteins</subject><subject>Carrier Proteins - administration & dosage</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - immunology</subject><subject>Confidence intervals</subject><subject>Conjugate vaccines</subject><subject>Diphtheria</subject><subject>Duty of care</subject><subject>Glycoconjugates - administration & dosage</subject><subject>Glycoconjugates - chemistry</subject><subject>Glycoconjugates - immunology</subject><subject>Haemophilus influenzae</subject><subject>Hemophilia</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant</subject><subject>Infants</subject><subject>Interchangeability</subject><subject>Interference</subject><subject>Meningitis</subject><subject>Meningococcal capsular group C</subject><subject>Meningococcal Vaccines - administration & dosage</subject><subject>Meningococcal Vaccines - chemistry</subject><subject>Meningococcal Vaccines - immunology</subject><subject>Neisseria meningitidis</subject><subject>Streptococcus pneumoniae</subject><subject>Tetanus</subject><subject>Toxins</subject><subject>Treatment Outcome</subject><subject>United Kingdom</subject><subject>Vaccines</subject><subject>Whooping 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month after the national UK schedule. • Infants could receive any of three meningococcal C conjugate vaccines at 3 and 4 months. • Responses were lower after CRM-conjugated followed by tetanus-conjugated MenC vaccine. • Conjugate vaccines with different carrier proteins may not be interchangeable. • When possible children should receive conjugate vaccines with the same carrier protein.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>25510388</pmid><doi>10.1016/j.vaccine.2014.12.018</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0856-2476</orcidid></addata></record> |
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| subjects | Age Allergy and Immunology Antibodies, Bacterial - blood Blood Blood Bactericidal Activity Carrier proteins Carrier Proteins - administration & dosage Carrier Proteins - chemistry Carrier Proteins - immunology Confidence intervals Conjugate vaccines Diphtheria Duty of care Glycoconjugates - administration & dosage Glycoconjugates - chemistry Glycoconjugates - immunology Haemophilus influenzae Hemophilia Humans Immunization Infant Infants Interchangeability Interference Meningitis Meningococcal capsular group C Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - chemistry Meningococcal Vaccines - immunology Neisseria meningitidis Streptococcus pneumoniae Tetanus Toxins Treatment Outcome United Kingdom Vaccines Whooping cough |
| title | Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule |
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