Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule

Highlights • Immune responses of infants were assessed 1 month after the national UK schedule. • Infants could receive any of three meningococcal C conjugate vaccines at 3 and 4 months. • Responses were lower after CRM-conjugated followed by tetanus-conjugated MenC vaccine. • Conjugate vaccines with...

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Veröffentlicht in:	Vaccine 2015-01, Vol.33 (5), p.648-655
Hauptverfasser:	Ladhani, Shamez N, Andrews, Nick J, Waight, Pauline, Hallis, Bassam, Matheson, Mary, England, Anna, Findlow, Helen, Bai, Xilian, Borrow, Ray, Burbidge, Polly, Pearce, Emma, Goldblatt, David, Miller, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology Antibodies, Bacterial - blood Blood Blood Bactericidal Activity Carrier proteins Carrier Proteins - administration & dosage Carrier Proteins - chemistry Carrier Proteins - immunology Confidence intervals Conjugate vaccines Diphtheria Duty of care Glycoconjugates - administration & dosage Glycoconjugates - chemistry Glycoconjugates - immunology Haemophilus influenzae Hemophilia Humans Immunization Infant Infants Interchangeability Interference Meningitis Meningococcal capsular group C Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - chemistry Meningococcal Vaccines - immunology Neisseria meningitidis Streptococcus pneumoniae Tetanus Toxins Treatment Outcome United Kingdom Vaccines Whooping cough
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Beschreibung
Zusammenfassung:	Highlights • Immune responses of infants were assessed 1 month after the national UK schedule. • Infants could receive any of three meningococcal C conjugate vaccines at 3 and 4 months. • Responses were lower after CRM-conjugated followed by tetanus-conjugated MenC vaccine. • Conjugate vaccines with different carrier proteins may not be interchangeable. • When possible children should receive conjugate vaccines with the same carrier protein.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.12.018