Protective immune response to liposome adjuvanted high potency foot-and-mouth disease vaccine in Indian cattle

Highlights • VacciMax adjuvant comprising poly I:C (VacciMax-A) confers 100% protection against FMD in cattle even after 6 months of booster. • Intramuscular administration is the preferred route for liposome based FMD vaccine. • The VacciMax-A adjuvant induces high level of neutralizing antibodies...

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Veröffentlicht in:	Vaccine 2015-01, Vol.33 (5), p.670-677
Hauptverfasser:	Saravanan, Paramasivam, Sreenivasa, B.P, Selvan, R.P. Tamil, Basagoudanavar, Suresh H, Hosamani, Madhusudan, Reddy, Nandakumar D, Nathanielsz, J, Derozier, Christophe, Venkataramanan, Ramamurthy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquisitions & mergers Adjuvant Adjuvants, Immunologic - administration & dosage Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Cattle Disease control Enzyme-Linked Immunosorbent Assay Experiments Foot & mouth disease Foot-and-Mouth Disease - immunology Foot-and-Mouth Disease - prevention & control Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - isolation & purification Herd immunity Immune response Immunization Liposome Liposomes - administration & dosage LPBE Neutralization Neutralization Tests Real-Time Polymerase Chain Reaction RNA, Viral - blood Serum - immunology VacciMax Vaccination - methods Vaccines Viral Load Viral Nonstructural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Viremia Virus challenge VNT
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Beschreibung
Zusammenfassung:	Highlights • VacciMax adjuvant comprising poly I:C (VacciMax-A) confers 100% protection against FMD in cattle even after 6 months of booster. • Intramuscular administration is the preferred route for liposome based FMD vaccine. • The VacciMax-A adjuvant induces high level of neutralizing antibodies against FMD virus that sustain over a period of one year.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.12.008