Acute increases in intramuscular inflammatory cytokines are necessary for the development of mechanical hypersensitivity in a mouse model of musculoskeletal sensitization

Highlights • Musculoskeletal pain, a major public health problem, is understudied pre-clinically. • Local intramuscular injections of acidified saline model facets of musculoskeletal pain. • IL-1 and IL-6, but not TNF, increase in muscle after injection of acidified saline. • Inhibiting NFκB in musc...

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