Acute increases in intramuscular inflammatory cytokines are necessary for the development of mechanical hypersensitivity in a mouse model of musculoskeletal sensitization

Highlights • Musculoskeletal pain, a major public health problem, is understudied pre-clinically. • Local intramuscular injections of acidified saline model facets of musculoskeletal pain. • IL-1 and IL-6, but not TNF, increase in muscle after injection of acidified saline. • Inhibiting NFκB in musc...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-02, Vol.44, p.213-220
Hauptverfasser:	Sutton, Blair C, Opp, Mark R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cytokines - metabolism Disease Models, Animal Hyperalgesia - chemically induced Hyperalgesia - metabolism IL-1 IL-6 Inflammation Interleukin-1 - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Male Mice Mice, Knockout Muscle pain Muscle, Skeletal Myalgia - chemically induced Myalgia - metabolism Myositis - chemically induced Myositis - metabolism Psychiatry Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - physiology Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - physiology TNF
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Beschreibung
Zusammenfassung:	Highlights • Musculoskeletal pain, a major public health problem, is understudied pre-clinically. • Local intramuscular injections of acidified saline model facets of musculoskeletal pain. • IL-1 and IL-6, but not TNF, increase in muscle after injection of acidified saline. • Inhibiting NFκB in muscle blocks allodynia after acidified saline injection. • IL-1 receptor KO mice and IL-6 KO mice do not develop allodynia in this model.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2014.10.009