Generalized Bullous Eruption after Routine Vaccination in a Child with Diffuse Cutaneous Mastocytosis

At 5 months of age, the patient received his scheduled 4-month vaccinations, including Haemophilus influenzae; protein-conjugated pneumococcal vaccine; poliomyelitis vaccine; diphtheria, pertussis, and tetanus toxoid; and rotavirus vaccine. Mast stell stabilizers such as cromolyn improve disease con...

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Veröffentlicht in:The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2013-01, Vol.1 (1), p.94-96
Hauptverfasser: Bankova, Lora G., MD, Walter, Jolan E., MD, PhD, Iyengar, Shuba R., MD, Lorenzo, Mayra E., MD, PhD, Hornick, Jason L., MD, PhD, Castells, Mariana C., MD, PhD
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container_title The journal of allergy and clinical immunology in practice (Cambridge, MA)
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creator Bankova, Lora G., MD
Walter, Jolan E., MD, PhD
Iyengar, Shuba R., MD
Lorenzo, Mayra E., MD, PhD
Hornick, Jason L., MD, PhD
Castells, Mariana C., MD, PhD
description At 5 months of age, the patient received his scheduled 4-month vaccinations, including Haemophilus influenzae; protein-conjugated pneumococcal vaccine; poliomyelitis vaccine; diphtheria, pertussis, and tetanus toxoid; and rotavirus vaccine. Mast stell stabilizers such as cromolyn improve disease control.9 In our experience, steroids are the preferred therapy for cases with blister formation, as has been previously reported in the literature.5 Our report shows the importance of considering all triggers for activation and degranulation in children with DCM. Besides anaphylaxis, severe generalized blister formation is also considered a life-threatening event, especially if evolving into the hemorrhagic form.
doi_str_mv 10.1016/j.jaip.2012.08.008
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subjects Abdomen
Adrenal Cortex Hormones - therapeutic use
Allergy and Immunology
Anti-Asthmatic Agents - therapeutic use
Biopsy
Blister - drug therapy
Blister - etiology
Blood
Cromolyn Sodium - therapeutic use
Exanthema - drug therapy
Exanthema - etiology
Humans
Immunization
Infant
Internal Medicine
Laboratories
Male
Mastocytosis, Cutaneous - complications
Mastocytosis, Cutaneous - diagnosis
Mastocytosis, Cutaneous - pathology
Mortality
Pediatrics
Vaccination - adverse effects
Vaccines
title Generalized Bullous Eruption after Routine Vaccination in a Child with Diffuse Cutaneous Mastocytosis
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