Generalized Bullous Eruption after Routine Vaccination in a Child with Diffuse Cutaneous Mastocytosis

At 5 months of age, the patient received his scheduled 4-month vaccinations, including Haemophilus influenzae; protein-conjugated pneumococcal vaccine; poliomyelitis vaccine; diphtheria, pertussis, and tetanus toxoid; and rotavirus vaccine. Mast stell stabilizers such as cromolyn improve disease control.9 In our experience, steroids are the preferred therapy for cases with blister formation, as has been previously reported in the literature.5 Our report shows the importance of considering all triggers for activation and degranulation in children with DCM. Besides anaphylaxis, severe generalized blister formation is also considered a life-threatening event, especially if evolving into the hemorrhagic form.