Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity

Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity

Highlights • Neonatal LPS exposure increased formalin-induced pain in preadolescent and adult rats. • LPS-induced hyperalgesia at PND 22 coincides with increased plasma IL-1β. • LPS-treated adult rats displayed sex-dependent alterations in hippocampal IL-1β. • Neonatal LPS exposure increased mast ce...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2015-02, Vol.44, p.235-246
Hauptverfasser: Zouikr, Ihssane, Ahmed, Abdulrzag F, Horvat, Jay C, Beagley, Kenneth W, Clifton, Vicki L, Ray, Allyson, Thorne, Rick F, Jarnicki, Andrew G, Hansbro, Philip M, Hodgson, Deborah M
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Animals, Newborn
Cell Count
Cell Degranulation
Cytokines
Degranulation
Encephalitis - chemically induced
Encephalitis - immunology
Encephalitis - metabolism
Female
Formaldehyde
Formalin test
Hippocampus
Hippocampus - immunology
Hippocampus - metabolism
IL-1β
Inflammation
Inflammation - chemically induced
Inflammation - immunology
Inflammation - metabolism
Interleukin-1beta - blood
Interleukin-1beta - immunology
Lipopolysaccharides
LPS
Male
Mast cell
Mast Cells - immunology
Mast Cells - physiology
Motor Activity
Neonatal immune challenge
Nociception - physiology
Pain
Pain - chemically induced
Pain - immunology
Pain Measurement
Psychiatry
Rats
Rats, Wistar
Salmonella enteritidis
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Beschreibung
Zusammenfassung:Highlights • Neonatal LPS exposure increased formalin-induced pain in preadolescent and adult rats. • LPS-induced hyperalgesia at PND 22 coincides with increased plasma IL-1β. • LPS-treated adult rats displayed sex-dependent alterations in hippocampal IL-1β. • Neonatal LPS exposure increased mast cell degranulation at PND 22 but not PNDs 80-97.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2014.10.014