Negative affectivity predicts decreased pain tolerance during low-grade inflammation in healthy women

Highlights • Stress sensitivity and immune activation interacted to increase sensitivity to pain. • Trait negative affect predicted lower pain tolerance under induced mild inflammation. • This interaction suggests a mechanism that may underlie functional pain symptoms.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-02, Vol.44, p.32-36
Hauptverfasser:	Lacourt, T.E, Houtveen, J.H, Veldhuijzen van Zanten, J.J.C.S, Bosch, J.A, Drayson, M.T, Van Doornen, L.J.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Affect Algometry Allergy and Immunology Cross-Over Studies Cytokines Experimental pain Female Human Humans Inflammation Inflammation - psychology Inflammatory response Interleukin-6 Life events Negative affect Negative affectivity Pain sensitivity Pain threshold Pain Threshold - psychology Pain tolerance Placebo Pressure pain Psychiatry Randomized control Salmonella typhi Stress Stress, Psychological Vaccination Vaccine Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Stress sensitivity and immune activation interacted to increase sensitivity to pain. • Trait negative affect predicted lower pain tolerance under induced mild inflammation. • This interaction suggests a mechanism that may underlie functional pain symptoms.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2014.10.003