STAT3 as a therapeutic target for Epstein-Barr virus (EBV) – associated nasopharyngeal carcinoma

Highlights ► STAT3’s potential involvement in EBV-associated NPC is discussed. ► STAT3 as a good target for NPC therapy and prevention. ► Mechanisms of STAT3 activation in NPC.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2013-04, Vol.330 (2), p.141-149
Hauptverfasser:	Ho, Yeung, Tsao, Sai-Wah, Zeng, Musheng, Lui, Vivian Wai Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Asian Americans Bone cancer Breast cancer Cancer therapies carcinoma EBV Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Nuclear Antigens - physiology Ethnicity Genomes head Head & neck cancer Head and neck cancers Hematology, Oncology and Palliative Medicine Human herpesvirus 4 Human papillomavirus Humans Infections Medical prognosis Molecular targeting Nasopharyngeal cancer Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - etiology Nasopharyngeal Neoplasms - virology neck oncogenic viruses Papillomaviridae Pathogenesis Prostate cancer Proteins Receptor, Epidermal Growth Factor - physiology Rodents STAT3 STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - physiology Studies Viral Matrix Proteins - physiology Viral Proteins - physiology
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Beschreibung
Zusammenfassung:	Highlights ► STAT3’s potential involvement in EBV-associated NPC is discussed. ► STAT3 as a good target for NPC therapy and prevention. ► Mechanisms of STAT3 activation in NPC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.11.052