Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: A study using a knock-in mouse model

Highlights • Mice with R420W mutation of RyR2 exhibit hypertrophy of lymphoid organs. • Phenotypic changes may imply existence of hereditary arrhythmia diseases. • Phenotypic changes may suggest the presence of the R420W mutation. • Sudden unexplained death cases with mutation may show such findings at autopsy. • Mouse model resembles the previously termed “status thymicolymphaticus”.