Targeting Th17 cells in autoimmune diseases

Highlights • T helper 17 (Th17) cells have important functions in immunity and pathologic inflammation. • Targeting Th17 cells rather than single effector cytokines may enhance efficacy. • Retinoid-related orphan receptor-γt (RORγt) and interleukin-23 (IL-23) coordinate pathogenic Th17 cell developm...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2014-10, Vol.35 (10), p.493-500
Hauptverfasser:	Yang, Jianfei, Sundrud, Mark S, Skepner, Jill, Yamagata, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals autoimmune diseases Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Drug Delivery Systems Humans IL-17 IL-23 Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology RORγt Small Molecule Libraries - pharmacology Th17 Cells - drug effects Th17 Cells - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • T helper 17 (Th17) cells have important functions in immunity and pathologic inflammation. • Targeting Th17 cells rather than single effector cytokines may enhance efficacy. • Retinoid-related orphan receptor-γt (RORγt) and interleukin-23 (IL-23) coordinate pathogenic Th17 cell development and function. • Much remains to be learned about how RORγt inverse agonists regulate transcription. • Monoclonal antibodies targeting the IL-23/IL-23R pathway show clinical promise.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2014.07.006