GnRH receptors and peptides: Skating backward

Highlights • Tail-less type I GnRH receptors are in fishes, not just mammals. • Mammalian GnRH1, vertebrate GnRH2 and dogfish GnRH3 exist in cartilaginous skate. • GnRH3 peptides are found in cartilaginous and lobe finned fishes, not just teleosts. • The GnRH system emerged in early bilaterian evolu...

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Veröffentlicht in:	General and comparative endocrinology 2014-12, Vol.209, p.118-134
Hauptverfasser:	Roch, Graeme J, Busby, Ellen R, Sherwood, Nancy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bilateria Branchiostoma lanceolatum Cartilaginous GnRH1 peptide Cartilaginous type I GnRH receptor Endocrinology & Metabolism Evolution, Molecular Gene Deletion GnRH synteny and phylogenetics GnRHR superfamily GnRHR synteny and phylogenetics Gonadotropin-Releasing Hormone - classification Gonadotropin-Releasing Hormone - genetics Gonadotropin-Releasing Hormone - metabolism Humans Invertebrates - genetics Marine Phylogeny Receptors, LHRH - genetics Receptors, LHRH - metabolism Reproduction - physiology Vertebrates - genetics
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Beschreibung
Zusammenfassung:	Highlights • Tail-less type I GnRH receptors are in fishes, not just mammals. • Mammalian GnRH1, vertebrate GnRH2 and dogfish GnRH3 exist in cartilaginous skate. • GnRH3 peptides are found in cartilaginous and lobe finned fishes, not just teleosts. • The GnRH system emerged in early bilaterian evolution. • Early chordate evolution shaped a GnRH system resembling that of extant vertebrates.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2014.07.025