Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signaling

Highlights • RANKL expression correlates with glioma invasiveness in vivo. • Tumoral RANKL increases astrocyte in the periphery of tumor. • RANKL activates astrocytes via canonical NF-κB signaling. • Activated astrocytes render glioma cells invasive by TGFb signaling.

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Veröffentlicht in:	Cancer letters 2014-10, Vol.353 (2), p.194-200
Hauptverfasser:	Kim, Jun-Kyum, Jin, Xiong, Sohn, Young-Woo, Jin, Xun, Jeon, Hee-Young, Kim, Eun-Jung, Ham, Seok Won, Jeon, Hye-Min, Chang, So-Young, Oh, Se-Yeong, Yin, Jinlong, Kim, Sung-Hak, Park, Jong Bae, Nakano, Ichiro, Kim, Hyunggee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocyte Astrocytes - physiology Brain cancer Brain Neoplasms - metabolism Brain Neoplasms - mortality Brain Neoplasms - pathology Brain research Cancer Cell Line, Tumor Cell Movement Cytokines - physiology Glioblastoma Glioblastoma - metabolism Glioblastoma - mortality Glioblastoma - pathology Hematology, Oncology and Palliative Medicine Homeostasis Humans Kaplan-Meier Estimate Laboratories Life sciences Ligands Medical prognosis Metastasis Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness Neoplasm Transplantation NF-kappa B - metabolism RANK Ligand - physiology RANKL signaling Signal Transduction Studies Tumor Microenvironment Tumor-invasive microenvironment Tumors
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Zusammenfassung:	Highlights • RANKL expression correlates with glioma invasiveness in vivo. • Tumoral RANKL increases astrocyte in the periphery of tumor. • RANKL activates astrocytes via canonical NF-κB signaling. • Activated astrocytes render glioma cells invasive by TGFb signaling.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.07.034