Immunopharmacological modulation of mast cells

Highlights • Mast cells play an important role in several pathophysiological conditions. • Several drugs modulate mast cell functions in vitro and/or in vivo. • The study of mast cell biology has suggested novel therapeutic targets. • The benefits versus the risks of mast cell-targeted drugs should...

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Veröffentlicht in:	Current opinion in pharmacology 2014-08, Vol.17, p.45-57
Hauptverfasser:	Borriello, Francesco, Granata, Francescopaolo, Varricchi, Gilda, Genovese, Arturo, Triggiani, Massimo, Marone, Gianni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Degranulation - drug effects Drug Design Humans Immunologic Factors - pharmacology Internal Medicine Mast Cells - drug effects Mast Cells - immunology Mastocytosis - drug therapy Mastocytosis - immunology Medical Education Molecular Targeted Therapy Signal Transduction - drug effects
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Beschreibung
Zusammenfassung:	Highlights • Mast cells play an important role in several pathophysiological conditions. • Several drugs modulate mast cell functions in vitro and/or in vivo. • The study of mast cell biology has suggested novel therapeutic targets. • The benefits versus the risks of mast cell-targeted drugs should be carefully evaluated.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2014.07.002