Antibacterial Activity of Some 5-Dialkylaminomethylhydantoins and Related Derivatives

In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hyd...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2013/10/01, Vol.61(10), pp.1090-1093
Hauptverfasser:	Fujisaki, Fumiko, Toyofuku, Keiko, Egami, Mayu, Ishida, Shiori, Nakamoto, Naho, Kashige, Nobuhiro, Miake, Fumio, Sumoto, Kunihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial activity C2-symmetrical twin-drug Escherichia coli Escherichia coli - drug effects hydantoin Hydantoins - chemical synthesis Hydantoins - chemistry Hydantoins - pharmacology Microbial Sensitivity Tests Staphylococcus aureus Staphylococcus aureus - drug effects Structure-Activity Relationship β-aminoalanine
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Zusammenfassung:	In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C2-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity against S. aureus strain.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c13-00461