A novel transcellular transport pathway for non-bile salt cholephilic organic anions

A novel transcellular transport pathway for non-bile salt cholephilic organic anions

Non-bile salt cholephilic organic anions comprise a single class of nonhomologous ligands having a range of hydrophobicity. Hydrophobicity enhances the hepatic extraction of cholephiles as well as their partitioning into secreted biliary lipid particles. When hydrophobicity is correlated with patter...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1991-01, Vol.261 (2), p.G305-G311
Hauptverfasser: Aoyama, N, Tokumo, H, Ohya, T, Chandler, K, Holzbach, R T
Format: Artikel
Sprache:eng
Schlagworte:
liver
mechanisms
rats
transport
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Zusammenfassung:Non-bile salt cholephilic organic anions comprise a single class of nonhomologous ligands having a range of hydrophobicity. Hydrophobicity enhances the hepatic extraction of cholephiles as well as their partitioning into secreted biliary lipid particles. When hydrophobicity is correlated with patterns of biliary excretion for studying transcellular transport, however, the more hydrophobic probes are unsuitable.
ISSN:0363-6143