Responses of carp hepatopancreatic 7-ethoxyresorufin-O-deethylase and glutathione-dependent enzymes to organic pollutants-a field study
Modulations of hepatopancreatic activities of cytochrome P4501A (CYP1A) and glutathione‐dependent enzymes were investigated in carp collected in five ponds with different levels of contamination. The CYP1A‐dependent 7‐ethoxyresorufin‐O‐deethylase activity was markedly induced by polycyclic aromatic...
Gespeichert in:
| Veröffentlicht in: | Environmental Toxicology and Chemistry 1997-07, Vol.16 (7), p.1410-1416 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1416 |
|---|---|
| container_issue | 7 |
| container_start_page | 1410 |
| container_title | Environmental Toxicology and Chemistry |
| container_volume | 16 |
| creator | Machala, Miroslav Petřivalský, Marek Nezveda, Karel Ulrich, Robert Dušek, Ladislav Piačka, Vladimír Svobodová, Zdenka |
| description | Modulations of hepatopancreatic activities of cytochrome P4501A (CYP1A) and glutathione‐dependent enzymes were investigated in carp collected in five ponds with different levels of contamination. The CYP1A‐dependent 7‐ethoxyresorufin‐O‐deethylase activity was markedly induced by polycyclic aromatic hydrocarbons present in the sediment at a total concentration of 0.9 mg/kg. Even a low organic contamination increased some of the glutathione‐dependent enzymatic activities, namely cytosolic glutathione reductase, glutathione S‐transferase toward 1‐chloro‐2,4‐dinitrobenzene, ethacrynic acid and l,2‐epoxy‐3‐(p‐nitrophenoxy)propane, and microsomal glutathione S‐transferase. These parameters should be considered as potential tools for the biomonitoring of exposure to chemicals and/or impacts of exposure. An example of a multivariate cluster and discriminant analysis of the obtained analytical and biochemical data proved to be very effectiv tools for the characterization of the level of contamination. |
| doi_str_mv | 10.1002/etc.5620160713 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_proquest_miscellaneous_16536631</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16536631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4053-1bcc83611c0aec40396d412e0e49099cd35b0256c7931d28f123513dd68b699a3</originalsourceid><addsrcrecordid>eNqFkU9rFDEYhwdRcK1ePUcQb1nzZ5KZHKVoLSwWtKK3kE3e6UZnkzHJYMcv0K9tli0VT3sKvHl-T97wa5qXlKwpIewtFLsWkhEqSUf5o2ZFhWC4l7R_3KxIxwnumOyfNs9y_kEqpZRaNXefIU8xZMgoDsiaNKEdTKbEyQSbwBRvUYeh7OLtkiDHNA8-4CvsoM6W0WRAJjh0M87FlJ2PAerVBMFBKAjCn2VfzSWimG5MqK4pjgc0lIwNGjyMDuUyu-V582QwY4YX9-dZ8_XD--vzj3hzdXF5_m6DbUsEx3Rrbc8lpZYYqCOupGspAwKtIkpZx8WWMCFtpzh1rB8o44Jy52S_rR82_Kx5dfTGXLzO1hewOxtDAFu0oK3oWGXeHJkpxV8z5KL3PlsYRxMgzllTKbiUnJ4G21Yw0fLTIJesrftXcH0EbYo5Jxj0lPzepEVTog8t69qy_tdyDby-N5tszTikWpvPDynWk151B686Yr_9CMsJqa7kf0_gY9bnArcPWZN-atnxTuhvny40_3It--9yo1v-F6m8yLw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13624099</pqid></control><display><type>article</type><title>Responses of carp hepatopancreatic 7-ethoxyresorufin-O-deethylase and glutathione-dependent enzymes to organic pollutants-a field study</title><source>Access via Wiley Online Library</source><creator>Machala, Miroslav ; Petřivalský, Marek ; Nezveda, Karel ; Ulrich, Robert ; Dušek, Ladislav ; Piačka, Vladimír ; Svobodová, Zdenka</creator><creatorcontrib>Machala, Miroslav ; Petřivalský, Marek ; Nezveda, Karel ; Ulrich, Robert ; Dušek, Ladislav ; Piačka, Vladimír ; Svobodová, Zdenka</creatorcontrib><description>Modulations of hepatopancreatic activities of cytochrome P4501A (CYP1A) and glutathione‐dependent enzymes were investigated in carp collected in five ponds with different levels of contamination. The CYP1A‐dependent 7‐ethoxyresorufin‐O‐deethylase activity was markedly induced by polycyclic aromatic hydrocarbons present in the sediment at a total concentration of 0.9 mg/kg. Even a low organic contamination increased some of the glutathione‐dependent enzymatic activities, namely cytosolic glutathione reductase, glutathione S‐transferase toward 1‐chloro‐2,4‐dinitrobenzene, ethacrynic acid and l,2‐epoxy‐3‐(p‐nitrophenoxy)propane, and microsomal glutathione S‐transferase. These parameters should be considered as potential tools for the biomonitoring of exposure to chemicals and/or impacts of exposure. An example of a multivariate cluster and discriminant analysis of the obtained analytical and biochemical data proved to be very effectiv tools for the characterization of the level of contamination.</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.5620160713</identifier><identifier>CODEN: ETOCDK</identifier><language>eng</language><publisher>Hoboken: Wiley Periodicals, Inc</publisher><subject>Agnatha. Pisces ; Animal, plant and microbial ecology ; Applied ecology ; Biological and medical sciences ; BIOLOGICAL INDICATORS ; BIOLOGICAL MARKERS ; BIOLOGICAL STRESS ; BIOLOGY AND MEDICINE, APPLIED STUDIES ; Biomarker ; Carp ; CYP1A ; Cyprinus carpio ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; ENVIRONMENTAL SCIENCES ; ENZYME ACTIVITY ; FIELD TESTS ; FISHES ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Glutathione enzymes ; OXIDOREDUCTASES ; POLYCYCLIC AROMATIC HYDROCARBONS ; WATER POLLUTION</subject><ispartof>Environmental Toxicology and Chemistry, 1997-07, Vol.16 (7), p.1410-1416</ispartof><rights>Copyright © 1997 SETAC</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4053-1bcc83611c0aec40396d412e0e49099cd35b0256c7931d28f123513dd68b699a3</citedby><cites>FETCH-LOGICAL-c4053-1bcc83611c0aec40396d412e0e49099cd35b0256c7931d28f123513dd68b699a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.5620160713$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.5620160713$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2808979$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/514572$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Machala, Miroslav</creatorcontrib><creatorcontrib>Petřivalský, Marek</creatorcontrib><creatorcontrib>Nezveda, Karel</creatorcontrib><creatorcontrib>Ulrich, Robert</creatorcontrib><creatorcontrib>Dušek, Ladislav</creatorcontrib><creatorcontrib>Piačka, Vladimír</creatorcontrib><creatorcontrib>Svobodová, Zdenka</creatorcontrib><title>Responses of carp hepatopancreatic 7-ethoxyresorufin-O-deethylase and glutathione-dependent enzymes to organic pollutants-a field study</title><title>Environmental Toxicology and Chemistry</title><addtitle>Environmental Toxicology and Chemistry</addtitle><description>Modulations of hepatopancreatic activities of cytochrome P4501A (CYP1A) and glutathione‐dependent enzymes were investigated in carp collected in five ponds with different levels of contamination. The CYP1A‐dependent 7‐ethoxyresorufin‐O‐deethylase activity was markedly induced by polycyclic aromatic hydrocarbons present in the sediment at a total concentration of 0.9 mg/kg. Even a low organic contamination increased some of the glutathione‐dependent enzymatic activities, namely cytosolic glutathione reductase, glutathione S‐transferase toward 1‐chloro‐2,4‐dinitrobenzene, ethacrynic acid and l,2‐epoxy‐3‐(p‐nitrophenoxy)propane, and microsomal glutathione S‐transferase. These parameters should be considered as potential tools for the biomonitoring of exposure to chemicals and/or impacts of exposure. An example of a multivariate cluster and discriminant analysis of the obtained analytical and biochemical data proved to be very effectiv tools for the characterization of the level of contamination.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL INDICATORS</subject><subject>BIOLOGICAL MARKERS</subject><subject>BIOLOGICAL STRESS</subject><subject>BIOLOGY AND MEDICINE, APPLIED STUDIES</subject><subject>Biomarker</subject><subject>Carp</subject><subject>CYP1A</subject><subject>Cyprinus carpio</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>ENVIRONMENTAL SCIENCES</subject><subject>ENZYME ACTIVITY</subject><subject>FIELD TESTS</subject><subject>FISHES</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione enzymes</subject><subject>OXIDOREDUCTASES</subject><subject>POLYCYCLIC AROMATIC HYDROCARBONS</subject><subject>WATER POLLUTION</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkU9rFDEYhwdRcK1ePUcQb1nzZ5KZHKVoLSwWtKK3kE3e6UZnkzHJYMcv0K9tli0VT3sKvHl-T97wa5qXlKwpIewtFLsWkhEqSUf5o2ZFhWC4l7R_3KxIxwnumOyfNs9y_kEqpZRaNXefIU8xZMgoDsiaNKEdTKbEyQSbwBRvUYeh7OLtkiDHNA8-4CvsoM6W0WRAJjh0M87FlJ2PAerVBMFBKAjCn2VfzSWimG5MqK4pjgc0lIwNGjyMDuUyu-V582QwY4YX9-dZ8_XD--vzj3hzdXF5_m6DbUsEx3Rrbc8lpZYYqCOupGspAwKtIkpZx8WWMCFtpzh1rB8o44Jy52S_rR82_Kx5dfTGXLzO1hewOxtDAFu0oK3oWGXeHJkpxV8z5KL3PlsYRxMgzllTKbiUnJ4G21Yw0fLTIJesrftXcH0EbYo5Jxj0lPzepEVTog8t69qy_tdyDby-N5tszTikWpvPDynWk151B686Yr_9CMsJqa7kf0_gY9bnArcPWZN-atnxTuhvny40_3It--9yo1v-F6m8yLw</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>Machala, Miroslav</creator><creator>Petřivalský, Marek</creator><creator>Nezveda, Karel</creator><creator>Ulrich, Robert</creator><creator>Dušek, Ladislav</creator><creator>Piačka, Vladimír</creator><creator>Svobodová, Zdenka</creator><general>Wiley Periodicals, Inc</general><general>SETAC</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>OTOTI</scope></search><sort><creationdate>199707</creationdate><title>Responses of carp hepatopancreatic 7-ethoxyresorufin-O-deethylase and glutathione-dependent enzymes to organic pollutants-a field study</title><author>Machala, Miroslav ; Petřivalský, Marek ; Nezveda, Karel ; Ulrich, Robert ; Dušek, Ladislav ; Piačka, Vladimír ; Svobodová, Zdenka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4053-1bcc83611c0aec40396d412e0e49099cd35b0256c7931d28f123513dd68b699a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL INDICATORS</topic><topic>BIOLOGICAL MARKERS</topic><topic>BIOLOGICAL STRESS</topic><topic>BIOLOGY AND MEDICINE, APPLIED STUDIES</topic><topic>Biomarker</topic><topic>Carp</topic><topic>CYP1A</topic><topic>Cyprinus carpio</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>ENVIRONMENTAL SCIENCES</topic><topic>ENZYME ACTIVITY</topic><topic>FIELD TESTS</topic><topic>FISHES</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione enzymes</topic><topic>OXIDOREDUCTASES</topic><topic>POLYCYCLIC AROMATIC HYDROCARBONS</topic><topic>WATER POLLUTION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machala, Miroslav</creatorcontrib><creatorcontrib>Petřivalský, Marek</creatorcontrib><creatorcontrib>Nezveda, Karel</creatorcontrib><creatorcontrib>Ulrich, Robert</creatorcontrib><creatorcontrib>Dušek, Ladislav</creatorcontrib><creatorcontrib>Piačka, Vladimír</creatorcontrib><creatorcontrib>Svobodová, Zdenka</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>OSTI.GOV</collection><jtitle>Environmental Toxicology and Chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machala, Miroslav</au><au>Petřivalský, Marek</au><au>Nezveda, Karel</au><au>Ulrich, Robert</au><au>Dušek, Ladislav</au><au>Piačka, Vladimír</au><au>Svobodová, Zdenka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responses of carp hepatopancreatic 7-ethoxyresorufin-O-deethylase and glutathione-dependent enzymes to organic pollutants-a field study</atitle><jtitle>Environmental Toxicology and Chemistry</jtitle><addtitle>Environmental Toxicology and Chemistry</addtitle><date>1997-07</date><risdate>1997</risdate><volume>16</volume><issue>7</issue><spage>1410</spage><epage>1416</epage><pages>1410-1416</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><coden>ETOCDK</coden><abstract>Modulations of hepatopancreatic activities of cytochrome P4501A (CYP1A) and glutathione‐dependent enzymes were investigated in carp collected in five ponds with different levels of contamination. The CYP1A‐dependent 7‐ethoxyresorufin‐O‐deethylase activity was markedly induced by polycyclic aromatic hydrocarbons present in the sediment at a total concentration of 0.9 mg/kg. Even a low organic contamination increased some of the glutathione‐dependent enzymatic activities, namely cytosolic glutathione reductase, glutathione S‐transferase toward 1‐chloro‐2,4‐dinitrobenzene, ethacrynic acid and l,2‐epoxy‐3‐(p‐nitrophenoxy)propane, and microsomal glutathione S‐transferase. These parameters should be considered as potential tools for the biomonitoring of exposure to chemicals and/or impacts of exposure. An example of a multivariate cluster and discriminant analysis of the obtained analytical and biochemical data proved to be very effectiv tools for the characterization of the level of contamination.</abstract><cop>Hoboken</cop><pub>Wiley Periodicals, Inc</pub><doi>10.1002/etc.5620160713</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0730-7268 |
| ispartof | Environmental Toxicology and Chemistry, 1997-07, Vol.16 (7), p.1410-1416 |
| issn | 0730-7268 1552-8618 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16536631 |
| source | Access via Wiley Online Library |
| subjects | Agnatha. Pisces Animal, plant and microbial ecology Applied ecology Biological and medical sciences BIOLOGICAL INDICATORS BIOLOGICAL MARKERS BIOLOGICAL STRESS BIOLOGY AND MEDICINE, APPLIED STUDIES Biomarker Carp CYP1A Cyprinus carpio Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates ENVIRONMENTAL SCIENCES ENZYME ACTIVITY FIELD TESTS FISHES Freshwater Fundamental and applied biological sciences. Psychology Glutathione enzymes OXIDOREDUCTASES POLYCYCLIC AROMATIC HYDROCARBONS WATER POLLUTION |
| title | Responses of carp hepatopancreatic 7-ethoxyresorufin-O-deethylase and glutathione-dependent enzymes to organic pollutants-a field study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A48%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Responses%20of%20carp%20hepatopancreatic%207-ethoxyresorufin-O-deethylase%20and%20glutathione-dependent%20enzymes%20to%20organic%20pollutants-a%20field%20study&rft.jtitle=Environmental%20Toxicology%20and%20Chemistry&rft.au=Machala,%20Miroslav&rft.date=1997-07&rft.volume=16&rft.issue=7&rft.spage=1410&rft.epage=1416&rft.pages=1410-1416&rft.issn=0730-7268&rft.eissn=1552-8618&rft.coden=ETOCDK&rft_id=info:doi/10.1002/etc.5620160713&rft_dat=%3Cproquest_osti_%3E16536631%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13624099&rft_id=info:pmid/&rfr_iscdi=true |