Factor VIII: Structure, function and analysis

Factor VIII: Structure, function and analysis

Factor VIII is an important blood coagulation protein whose genetic deficiency leads to the serious bleeding disorder, classic haemophilia (haemophilia A). Here we review the structure, function and analysis of this protein for diagnostic and theraputic applications. Because factor VIII is tightly a...

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Veröffentlicht in:Biotechnology Advances 1993, Vol.11 (1), p.79-114
Hauptverfasser: Fiona, Manning, Ciarán, Ó^Fágáin, Richard, O'Kennedy
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Blood coagulation. Blood cells
Classic haemophilia (haemophilia A)
Coagulation factors
Factor VIII
Factor VIII assay
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
von Willebrand factor
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Zusammenfassung:Factor VIII is an important blood coagulation protein whose genetic deficiency leads to the serious bleeding disorder, classic haemophilia (haemophilia A). Here we review the structure, function and analysis of this protein for diagnostic and theraputic applications. Because factor VIII is tightly associated with von Willebrand factor some recent work on the latter is also considered so as to clarify the relationship between them.
ISSN:0734-9750
1873-1899
DOI:10.1016/0734-9750(93)90410-O