Molecular mechanisms involved in lead induced disruption of hepatic and pancreatic glucose metabolism

Highlights • Lead can disrupt glucose homeostasis by affecting pancreas and liver. • It impairs insulin secretion from pancreas through endoplasmic reticulum stress. • Inhibitory effect of insulin on gluconeogenesis in liver was impaired by lead. • Chronic exposure to lead can be a risk factor for i...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2015-01, Vol.39 (1), p.16-26
Hauptverfasser:	Mostafalou, Sara, Baeeri, Maryam, Bahadar, Haji, Soltany-Rezaee-Rad, Mohammad, Gholami, Mahdi, Abdollahi, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Emergency Endoplasmic Reticulum Stress - drug effects Glucose - metabolism Glucose homeostasis Glucose-6-Phosphatase - metabolism Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Insulin - blood Insulin - metabolism Insulin Resistance Intracellular Signaling Peptides and Proteins - metabolism Islets of Langerhans - drug effects Islets of Langerhans - metabolism Lead (Pb) Liver Liver - drug effects Liver - metabolism Male Organometallic Compounds - blood Organometallic Compounds - pharmacokinetics Organometallic Compounds - toxicity Pancreatic islets Phosphoenolpyruvate Carboxykinase (GTP) - metabolism Rats, Wistar Reactive Oxygen Species - metabolism
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Zusammenfassung:	Highlights • Lead can disrupt glucose homeostasis by affecting pancreas and liver. • It impairs insulin secretion from pancreas through endoplasmic reticulum stress. • Inhibitory effect of insulin on gluconeogenesis in liver was impaired by lead. • Chronic exposure to lead can be a risk factor for insulin resistance and diabetes.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.11.001