A 2-DE-based proteomic study on the toxicological effects of cisplatin in L02 cells

A 2-DE-based proteomic study on the toxicological effects of cisplatin in L02 cells

Highlights • Cisplatin induced disturbances in primary metabolism and cytoskeleton in L02 cells. • Cisplatin exposures (1 nM, 1 μM and 1 mM) caused oxidative stress in L02 cells. • Proteomics didn’t show cisplatin-induced hormetic effects in L02 cells.

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Bibliographische Detailangaben
Veröffentlicht in:Environmental toxicology and pharmacology 2015-01, Vol.39 (1), p.167-175
Hauptverfasser: Liu, Shu, Wang, Wei, Zhou, Xueyi, Ding, Zongli, Gu, Runhuan
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - toxicity
Cell Line
Cisplatin
Cisplatin - toxicity
Dose-Response Relationship, Drug
Electrophoresis, Gel, Two-Dimensional
Emergency
Humans
L02 cell
Oxidative Stress - drug effects
Proteomics
Toxicological effects
Two-dimensional electrophoresis
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Zusammenfassung:Highlights • Cisplatin induced disturbances in primary metabolism and cytoskeleton in L02 cells. • Cisplatin exposures (1 nM, 1 μM and 1 mM) caused oxidative stress in L02 cells. • Proteomics didn’t show cisplatin-induced hormetic effects in L02 cells.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2014.11.018