Metformin versus insulin treatment in gestational diabetes in pregnancy in a developing country. A randomized control trial

Highlights. • A randomized control trial was conducted in two hospitals from two districts of Karachi, comparing metformin with insulin treatment in GDM. • Metformin exerted better effects on neonatal and maternal outcomes than on the glycemic profiles in women with GDM. • Less weight gain in pregnancy and lower rates of pre eclampsia was found in metformin treated patients with GDM. • Metformin with or without supplemental insulin is a cheap, cost effective treatment option for women with GDM.