Eosinophils and itch: Partners in crime or strange bedfellows?

[...]through measurements of ear thickness, the authors show that edematous reactions in ear skin after contact exposure to TMA are greater in both PHIL and wild-type mice compared with those seen in ears of vehicle-treated (control) mice but that, similar to histologic comparisons, PHIL mice have less skin edema than wild-type mice. [...]the investigators show that eosinophil degranulation is greater in TMA-treated ears of wild-type mice than in vehicle-treated ears, with essentially no eosinophil degranulation in either TMA- or vehicle-treated ears of PHIL mice.