Chromosomal location and isoform analysis of mouse Fc sub( epsilon ) RII/CD23

The gene for the mouse low affinity receptor for IgE (Fc sub( epsilon )RII, also known as CD23) was mapped on Chromosome (Chr) 8 proximal to Plat. This gene, symbolized Fcer2 (formerly Fce2) resides in a region of Chr 8 with linkage homology with human chromosomes 8 and 19. The mouse Fc sub( epsilon )RII was examined for the presence of alternate N-terminal forms such as seen in humans. The results suggests that the mouse does not produce significant levels of an alternate IL-4 inducible Fc sub( epsilon )RII, as seen in man, and this may explain the more restricted cell lineage expression of the Fc sub( epsilon )RII in the mouse.