Cu-Catalyzed Aerobic Oxidative Esterification of Acetophenones with Alcohols to α‑Ketoesters

Cu-Catalyzed Aerobic Oxidative Esterification of Acetophenones with Alcohols to α‑Ketoesters

Copper-catalyzed aerobic oxidative esterification of acetophenones with alcohols using molecular oxygen has been developed to form a broad range of α-ketoesters in good yields. In addition to reporting scope and limitations of our new method, mechanism studies are reported that reveal that the carbo...

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Veröffentlicht in:Organic letters 2015-02, Vol.17 (3), p.516-519
Hauptverfasser: Xu, Xuezhao, Ding, Wen, Lin, Yuanguang, Song, Qiuling
Format: Artikel
Sprache:eng
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Zusammenfassung:Copper-catalyzed aerobic oxidative esterification of acetophenones with alcohols using molecular oxygen has been developed to form a broad range of α-ketoesters in good yields. In addition to reporting scope and limitations of our new method, mechanism studies are reported that reveal that the carbonyl oxygen in the ester mainly originated from dioxygen.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol503472x