Reproducibility: Standardize antibodies used in research

To save millions of dollars and dramatically improve reproducibility, protein-binding reagents must be defined by their sequences and produced as recombinant proteins, say Andrew Bradbury, Andreas Plückthun and 110 co-signatories.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2015-02, Vol.518 (7537), p.27-29
Hauptverfasser:	Bradbury, Andrew, Plückthun, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61 631/80 706/648/496 706/648/697/129 Amino Acid Sequence Antibodies - chemistry Antibodies - economics Antibodies - immunology Antibodies - isolation & purification Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Antibody Specificity Biomedical Research - standards comment Humanities and Social Sciences Hybridomas - cytology Hybridomas - immunology Hybridomas - metabolism Immune Sera - immunology Indicators and Reagents - economics multidisciplinary Quality Control Recombinant Proteins - biosynthesis Recombinant Proteins - economics Recombinant Proteins - immunology Recombinant Proteins - isolation & purification Reproducibility of Results Science
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Beschreibung
Zusammenfassung:	To save millions of dollars and dramatically improve reproducibility, protein-binding reagents must be defined by their sequences and produced as recombinant proteins, say Andrew Bradbury, Andreas Plückthun and 110 co-signatories.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/518027a