miRNAs as biomarkers of myocardial infarction: a step forward towards personalized medicine?

Highlights • Circulating levels of cardiac-enriched miRNAs are increased after myocardial infarction (MI). • Circulating miRNAs do not outperform troponins for the diagnosis of MI. • Some miRNAs or panels of miRNAs have a promising prognostic value after MI. • An emerging concept is that miRNAs may...

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Veröffentlicht in:	Trends in molecular medicine 2014-12, Vol.20 (12), p.716-725
Hauptverfasser:	Goretti, Emeline, Wagner, Daniel R, Devaux, Yvan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biomarker Disease Models, Animal Gene Expression Regulation Genetic Markers Humans MicroRNAs - blood MicroRNAs - genetics miRNAs myocardial infarction Myocardial Infarction - diagnosis Myocardial Infarction - genetics Myocardial Infarction - therapy Pathology personalized medicine Precision Medicine - methods Prognosis therapeutic targets Treatment Outcome Troponin - genetics Troponin - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Circulating levels of cardiac-enriched miRNAs are increased after myocardial infarction (MI). • Circulating miRNAs do not outperform troponins for the diagnosis of MI. • Some miRNAs or panels of miRNAs have a promising prognostic value after MI. • An emerging concept is that miRNAs may be used for personalized medicine.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2014.10.006