In vitro and in vivo anti-MRSA activities of nosokomycins

The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2...

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Veröffentlicht in:	Drug Discoveries & Therapeutics 2014/12/31, Vol.8(6), pp.249-254
Hauptverfasser:	Uchida, Ryuji, Hanaki, Hideaki, Matsui, Hidenori, Hamamoto, Hiroshi, Sekimizu, Kazuhisa, Iwatsuki, Masato, Kim, Yong Pil, Tomoda, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology anti-MRSA antibiotic Bacteria - drug effects Bombyx Dose-Response Relationship, Drug Humans Larva Methicillin-Resistant Staphylococcus aureus - drug effects Mice Microbial Sensitivity Tests Nosokomycins silkworm infection assay Streptococcal Infections - microbiology Streptomyces - chemistry Streptomyces cyslabdanicus K04-0144 therapeutic efficacy Vancomycin - therapeutic use
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Zusammenfassung:	The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model.
ISSN:	1881-7831 1881-784X
DOI:	10.5582/ddt.2014.01050