The role of IL-21 in immunity and cancer

Highlights • IL-21 is mainly produced by CD4+ T cells and natural killer T (NKT) cells. • IL-21 is a new member of the common γ-chain family of cytokines. • IL-21 is implicated in many immunological processes and development of inflammation and cancer. • Summarizing the advances of the role of IL-21...

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Veröffentlicht in:	Cancer letters 2015-03, Vol.358 (2), p.107-114
Hauptverfasser:	Davis, Matthew R, Zhu, Ziwen, Hansen, Dwayne M, Bai, Qian, Fang, Yujiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antibody Formation Antigens Apoptosis Autoimmune diseases B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Bladder cancer Cancer Cancer therapies CD4 antigen Cell Communication Cell Differentiation Cell growth Cytokines Cytotoxicity Gene Expression Germinal Center - immunology Germinal Center - metabolism Hematology, Oncology and Palliative Medicine Humans IL-21 Immune response Immunity Immunologic Memory Immunology Immunotherapy Inflammatory diseases Interleukin 21 Interleukins - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Activation Lymphocytes Lymphocytes T Mutation Natural killer cells Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Neovascularization, Pathologic - metabolism Pathogenesis Plasma Cells - cytology Plasma Cells - immunology Plasma Cells - metabolism Radiation therapy Radiation-Sensitizing Agents - metabolism Radiotherapy Receptors, Interleukin-21 - genetics Receptors, Interleukin-21 - metabolism Signal Transduction T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tumors
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Beschreibung
Zusammenfassung:	Highlights • IL-21 is mainly produced by CD4+ T cells and natural killer T (NKT) cells. • IL-21 is a new member of the common γ-chain family of cytokines. • IL-21 is implicated in many immunological processes and development of inflammation and cancer. • Summarizing the advances of the role of IL-21 in immunological processes and the pathogenesis of cancer.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.12.047