Atom-Economical Transformation of Diaryliodonium Salts: Tandem C–H and N–H Arylation of Indoles
Arylation using diaryliodonium salts generates one equivalent of an iodoarene as a side-product, a significant waste of atom economy. Here, we show that diaryliodoniums can undergo Cu-catalyzed tandem C–H/N–H arylation, producing novel indoles that incorporate both aryl groups from the reagent.
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| Veröffentlicht in: | Journal of the American Chemical Society 2015-02, Vol.137 (4), p.1416-1419 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 137 |
| creator | Modha, Sachin G Greaney, Michael F |
| description | Arylation using diaryliodonium salts generates one equivalent of an iodoarene as a side-product, a significant waste of atom economy. Here, we show that diaryliodoniums can undergo Cu-catalyzed tandem C–H/N–H arylation, producing novel indoles that incorporate both aryl groups from the reagent. |
| doi_str_mv | 10.1021/ja5124754 |
| format | Article |
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| ispartof | Journal of the American Chemical Society, 2015-02, Vol.137 (4), p.1416-1419 |
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| language | eng |
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| source | ACS Publications |
| title | Atom-Economical Transformation of Diaryliodonium Salts: Tandem C–H and N–H Arylation of Indoles |
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