Atom-Economical Transformation of Diaryliodonium Salts: Tandem C–H and N–H Arylation of Indoles
Arylation using diaryliodonium salts generates one equivalent of an iodoarene as a side-product, a significant waste of atom economy. Here, we show that diaryliodoniums can undergo Cu-catalyzed tandem C–H/N–H arylation, producing novel indoles that incorporate both aryl groups from the reagent.
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| Veröffentlicht in: | Journal of the American Chemical Society 2015-02, Vol.137 (4), p.1416-1419 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Arylation using diaryliodonium salts generates one equivalent of an iodoarene as a side-product, a significant waste of atom economy. Here, we show that diaryliodoniums can undergo Cu-catalyzed tandem C–H/N–H arylation, producing novel indoles that incorporate both aryl groups from the reagent. |
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| ISSN: | 0002-7863 1520-5126 |
| DOI: | 10.1021/ja5124754 |