Pentraxin-3 and VEGF in POEMS syndrome: A 2-year longitudinal study

Abstract Circulating Pentraxin 3 (PTX3) and vascular endothelial growth factor (VEGF) levels were measured longitudinally (mean follow-up 2 years) by ELISA in 6 patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome and 16 controls. Expression of PTX3 wa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neuroimmunology 2014-12, Vol.277 (1), p.189-192
Hauptverfasser:	Briani, Chiara, Torre, Chiara Dalla, Lessi, Federica, Cavallaro, Tiziana, Scarlato, Marina, Ferrari, Sergio, Campagnolo, Marta, Lucchetta, Marta, Cabrini, Ilaria, Morbin, Michela, Lauria, Giuseppe, Adami, Fausto, Manfredi, Angelo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergy and Immunology C-Reactive Protein - metabolism Female Humans Longitudinal Studies Male Middle Aged Neurology Pentraxin 3 POEMS syndrome POEMS Syndrome - metabolism POEMS Syndrome - pathology Polyneuropathy Serum Amyloid P-Component - metabolism Statistics, Nonparametric Sural Nerve - metabolism Vascular endothelial growth factor (VEGF) Vascular Endothelial Growth Factor A - blood Vasculitis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Circulating Pentraxin 3 (PTX3) and vascular endothelial growth factor (VEGF) levels were measured longitudinally (mean follow-up 2 years) by ELISA in 6 patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome and 16 controls. Expression of PTX3 was also assessed (immunohistochemistry) on sural nerve biopsies from POEMS and vasculitic neuropathy patients. No correlation was found between PTX3 and VEGF levels in POEMS or controls. Sural nerve biopsies from vasculitic neuropathy patients, but not those from POEMS syndrome, showed strong PTX3 staining. PTX3, expression of vessel inflammation/remodeling, and VEGF, crucial pro-angiogenic cytokine, appear to be independently regulated in POEMS syndrome.
ISSN:	0165-5728 1872-8421
DOI:	10.1016/j.jneuroim.2014.09.021