Effect of immunization against GnRH on hypothalamic and testicular function in rams

The objective was to determine effects of active immunization against GnRH on reproductive function in Tibetan rams. Peripubertal Tibetan rams (n = 30) were randomly and equally allocated into three groups: control (no treatment); surgically castrated; or immunized against 100-μg d-Lys6-GnRH-tandem-...

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Veröffentlicht in:Theriogenology 2015-03, Vol.83 (4), p.642-649
Hauptverfasser: Han, Xingfa, Gu, Longjun, Xia, Chenyang, Feng, Jing, Cao, Xiaohan, Du, Xiaogang, Zeng, Xianyin, Song, Tianzeng
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Sprache:eng
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Zusammenfassung:The objective was to determine effects of active immunization against GnRH on reproductive function in Tibetan rams. Peripubertal Tibetan rams (n = 30) were randomly and equally allocated into three groups: control (no treatment); surgically castrated; or immunized against 100-μg d-Lys6-GnRH-tandem-dimer peptide conjugated to ovalbumin in Specol adjuvant at 24 weeks of age (with a booster 8 weeks later). Blood samples (for antibody titers and hormone concentrations) were collected at 4-week intervals until rams were killed (40 weeks). Immunization triggered a good antibody response in all immunized rams (P 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2014.10.029