Activating Na+ –K+ ATPase: A potential cardioprotective therapy during early hemorrhagic shock

Abstract Cell volume and resting potential are heavily affected by the activity of Na+ –K+ ATPase (NKA, Na+ –K+ pump), an essential membrane protein that regulates plasma K+ and Na+ levels. It is generally accepted that the ineffective perfusion of body tissues inhibits NKA activity and that NKA activity and heart failure are closely related. Recently, research has proven that the activation of NKA provides significant cardioprotection against ischemic injury. Based on these data, we propose that NKA stimulation could attenuate the development of heart arrhythmia during the early phase of hemorrhagic shock.