Effect of acyclic monoterpene alcohols and their derivatives on TRP channels

X=O, NH; R=CH3, Aryl, Aralkyl, OAryl, NHAryl, NHAlkyl. [Display omitted] A series of thirty-six geraniol, nerol, citronellol, geranylamine, and nerylamine derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Most of them acted as strong modulators of TRPA1 channels with EC50 a...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-12, Vol.24 (23), p.5507-5511
Hauptverfasser:	Ortar, Giorgio, Schiano Moriello, Aniello, Morera, Enrico, Nalli, Marianna, Di Marzo, Vincenzo, De Petrocellis, Luciano
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclic monoterpene alcohols Alcohols Humans Monoterpenes - metabolism Transient receptor potential channels Transient Receptor Potential Channels - antagonists & inhibitors TRPA1 TRPM8 TRPV1
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	X=O, NH; R=CH3, Aryl, Aralkyl, OAryl, NHAryl, NHAlkyl. [Display omitted] A series of thirty-six geraniol, nerol, citronellol, geranylamine, and nerylamine derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Most of them acted as strong modulators of TRPA1 channels with EC50 and/or IC50 values
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2014.10.012