QuantiFERON–TB Gold In-Tube test performance in Denmark

Summary Background Little is known about the QuantiFERON-TB Gold In-Tube Test (QFT) in extreme age groups. The test performance has been reported to be impaired in children and elderly, but reports are diverging. The aim of this study was to evaluate QFT performance in patients with and without Tube...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2014-12, Vol.94 (6), p.616-621
Hauptverfasser:	Hermansen, Thomas, Lillebaek, Troels, Hansen, Ann-Brit E, Andersen, Peter H, Ravn, Pernille
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Child Children Elderly Female Humans Infant Infectious Disease Interferon-gamma - biosynthesis Interferon-gamma - blood Interferon-gamma-release assay Latent M. tuberculosis infection Latent Tuberculosis - diagnosis Male Middle Aged Pulmonary/Respiratory Reagent Kits, Diagnostic Retrospective Studies Sensitivity Sensitivity and Specificity Young Adult
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Zusammenfassung:	Summary Background Little is known about the QuantiFERON-TB Gold In-Tube Test (QFT) in extreme age groups. The test performance has been reported to be impaired in children and elderly, but reports are diverging. The aim of this study was to evaluate QFT performance in patients with and without Tuberculosis (TB). Methods A retrospective study analysing the results of 18,850 QFT performed in Denmark 2005-2010. The effect of age, sex, localisation of TB, and result of culture on QFT performance (positive, negative and indeterminate results) was determined. Results Among 383 patients with TB, indeterminate rate was low (3.9%, 15/383). Sensitivity was high (86.1%, 317/368) and not affected by sex or localization of TB disease, but declined with increasing age ( p
ISSN:	1472-9792 1873-281X
DOI:	10.1016/j.tube.2014.09.003