miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ
Highlights • The expression of REGγ is dysregulated in breast cancer. • The knockdown of REGγ inhibits cancer cell progression in vitro. • REGγ was identified as a downstream target gene of miR-7-5p. • The overexpression of miR-7-5p exerted anti-tumor effects mainly by targeting REGγ in vitro and in...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 2015-03, Vol.358 (1), p.27-36 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 36 |
|---|---|
| container_issue | 1 |
| container_start_page | 27 |
| container_title | Cancer letters |
| container_volume | 358 |
| creator | Shi, Yuan Luo, Xinrong Li, Peng Tan, Jinxiang Wang, Xiaoyi Xiang, Tingxiu Ren, Guosheng |
| description | Highlights • The expression of REGγ is dysregulated in breast cancer. • The knockdown of REGγ inhibits cancer cell progression in vitro. • REGγ was identified as a downstream target gene of miR-7-5p. • The overexpression of miR-7-5p exerted anti-tumor effects mainly by targeting REGγ in vitro and in vivo. • There is an inverse correlation between the expression of REGγ and miR-7-5p. |
| doi_str_mv | 10.1016/j.canlet.2014.12.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652417369</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0304383514007575</els_id><sourcerecordid>1652417369</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-bcc5e28a7aa1bd4f11016f60c11a0987ae26bad1866a9ded3e2db74e485985fe3</originalsourceid><addsrcrecordid>eNqFUU1v1TAQtBCIvhb-AUI-cknwOnacd0FCVWmRKiEVOFuOvan8yBfepNL7XfwPfhMOr3DgwmkOO7OzM8vYKxAlCKjfHkrvxh6XUgpQJcgywxO2g8bIwuwb8ZTtRCVUUTWVPmPnRAchhFZGP2dnUmsAo-SODUO8K0yhZ07rPCckQuIe-57Paepjh8ktcRq5GwOPY1h9Hrt5mpeJIvGp421CRwvPt3hMv5XEBxfH_sjbI19cuscljvf87ur6548X7FnnesKXj3jBvn64-nJ5U9x-uv54-f628ArMUrTea5SNM85BG1QHW-CuFh7AiX1jHMq6dQGaunb7gKFCGVqjUDV63-gOqwv25rQ3h_i-Ii12iLTd5kacVrJQa5mdqnqfqepE9WkiStjZOcXBpaMFYTdfe7Cnou1WtAVpM2TZ60eHtR0w_BX9aTYT3p0ImHM-REyWfMRcUogJ_WLDFP_n8O8C38cxetd_wyPSYVrTmDu0YCkL7Oft2duvQQlhtNHVL6HWp4U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652417369</pqid></control><display><type>article</type><title>miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Shi, Yuan ; Luo, Xinrong ; Li, Peng ; Tan, Jinxiang ; Wang, Xiaoyi ; Xiang, Tingxiu ; Ren, Guosheng</creator><creatorcontrib>Shi, Yuan ; Luo, Xinrong ; Li, Peng ; Tan, Jinxiang ; Wang, Xiaoyi ; Xiang, Tingxiu ; Ren, Guosheng</creatorcontrib><description>Highlights • The expression of REGγ is dysregulated in breast cancer. • The knockdown of REGγ inhibits cancer cell progression in vitro. • REGγ was identified as a downstream target gene of miR-7-5p. • The overexpression of miR-7-5p exerted anti-tumor effects mainly by targeting REGγ in vitro and in vivo. • There is an inverse correlation between the expression of REGγ and miR-7-5p.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2014.12.014</identifier><identifier>PMID: 25511742</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Apoptosis - genetics ; Autoantigens - biosynthesis ; Autoantigens - genetics ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cell Proliferation - genetics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Hematology, Oncology and Palliative Medicine ; Humans ; MCF-7 Cells ; MicroRNAs - genetics ; miR-7-5p ; Proliferation ; Proteasome Endopeptidase Complex - biosynthesis ; Proteasome Endopeptidase Complex - genetics ; REGγ ; Xenograft Model Antitumor Assays</subject><ispartof>Cancer letters, 2015-03, Vol.358 (1), p.27-36</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-bcc5e28a7aa1bd4f11016f60c11a0987ae26bad1866a9ded3e2db74e485985fe3</citedby><cites>FETCH-LOGICAL-c417t-bcc5e28a7aa1bd4f11016f60c11a0987ae26bad1866a9ded3e2db74e485985fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383514007575$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25511742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Yuan</creatorcontrib><creatorcontrib>Luo, Xinrong</creatorcontrib><creatorcontrib>Li, Peng</creatorcontrib><creatorcontrib>Tan, Jinxiang</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Xiang, Tingxiu</creatorcontrib><creatorcontrib>Ren, Guosheng</creatorcontrib><title>miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • The expression of REGγ is dysregulated in breast cancer. • The knockdown of REGγ inhibits cancer cell progression in vitro. • REGγ was identified as a downstream target gene of miR-7-5p. • The overexpression of miR-7-5p exerted anti-tumor effects mainly by targeting REGγ in vitro and in vivo. • There is an inverse correlation between the expression of REGγ and miR-7-5p.</description><subject>Apoptosis - genetics</subject><subject>Autoantigens - biosynthesis</subject><subject>Autoantigens - genetics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Proliferation - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Knockdown Techniques</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>MCF-7 Cells</subject><subject>MicroRNAs - genetics</subject><subject>miR-7-5p</subject><subject>Proliferation</subject><subject>Proteasome Endopeptidase Complex - biosynthesis</subject><subject>Proteasome Endopeptidase Complex - genetics</subject><subject>REGγ</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1TAQtBCIvhb-AUI-cknwOnacd0FCVWmRKiEVOFuOvan8yBfepNL7XfwPfhMOr3DgwmkOO7OzM8vYKxAlCKjfHkrvxh6XUgpQJcgywxO2g8bIwuwb8ZTtRCVUUTWVPmPnRAchhFZGP2dnUmsAo-SODUO8K0yhZ07rPCckQuIe-57Paepjh8ktcRq5GwOPY1h9Hrt5mpeJIvGp421CRwvPt3hMv5XEBxfH_sjbI19cuscljvf87ur6548X7FnnesKXj3jBvn64-nJ5U9x-uv54-f628ArMUrTea5SNM85BG1QHW-CuFh7AiX1jHMq6dQGaunb7gKFCGVqjUDV63-gOqwv25rQ3h_i-Ii12iLTd5kacVrJQa5mdqnqfqepE9WkiStjZOcXBpaMFYTdfe7Cnou1WtAVpM2TZ60eHtR0w_BX9aTYT3p0ImHM-REyWfMRcUogJ_WLDFP_n8O8C38cxetd_wyPSYVrTmDu0YCkL7Oft2duvQQlhtNHVL6HWp4U</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Shi, Yuan</creator><creator>Luo, Xinrong</creator><creator>Li, Peng</creator><creator>Tan, Jinxiang</creator><creator>Wang, Xiaoyi</creator><creator>Xiang, Tingxiu</creator><creator>Ren, Guosheng</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ</title><author>Shi, Yuan ; Luo, Xinrong ; Li, Peng ; Tan, Jinxiang ; Wang, Xiaoyi ; Xiang, Tingxiu ; Ren, Guosheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-bcc5e28a7aa1bd4f11016f60c11a0987ae26bad1866a9ded3e2db74e485985fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Apoptosis - genetics</topic><topic>Autoantigens - biosynthesis</topic><topic>Autoantigens - genetics</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Proliferation - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>MCF-7 Cells</topic><topic>MicroRNAs - genetics</topic><topic>miR-7-5p</topic><topic>Proliferation</topic><topic>Proteasome Endopeptidase Complex - biosynthesis</topic><topic>Proteasome Endopeptidase Complex - genetics</topic><topic>REGγ</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Yuan</creatorcontrib><creatorcontrib>Luo, Xinrong</creatorcontrib><creatorcontrib>Li, Peng</creatorcontrib><creatorcontrib>Tan, Jinxiang</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Xiang, Tingxiu</creatorcontrib><creatorcontrib>Ren, Guosheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Yuan</au><au>Luo, Xinrong</au><au>Li, Peng</au><au>Tan, Jinxiang</au><au>Wang, Xiaoyi</au><au>Xiang, Tingxiu</au><au>Ren, Guosheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>358</volume><issue>1</issue><spage>27</spage><epage>36</epage><pages>27-36</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights • The expression of REGγ is dysregulated in breast cancer. • The knockdown of REGγ inhibits cancer cell progression in vitro. • REGγ was identified as a downstream target gene of miR-7-5p. • The overexpression of miR-7-5p exerted anti-tumor effects mainly by targeting REGγ in vitro and in vivo. • There is an inverse correlation between the expression of REGγ and miR-7-5p.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25511742</pmid><doi>10.1016/j.canlet.2014.12.014</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2015-03, Vol.358 (1), p.27-36 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1652417369 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Apoptosis - genetics Autoantigens - biosynthesis Autoantigens - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Proliferation - genetics Female Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Hematology, Oncology and Palliative Medicine Humans MCF-7 Cells MicroRNAs - genetics miR-7-5p Proliferation Proteasome Endopeptidase Complex - biosynthesis Proteasome Endopeptidase Complex - genetics REGγ Xenograft Model Antitumor Assays |
| title | miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T06%3A29%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=miR-7-5p%20suppresses%20cell%20proliferation%20and%20induces%20apoptosis%20of%20breast%20cancer%20cells%20mainly%20by%20targeting%20REG%CE%B3&rft.jtitle=Cancer%20letters&rft.au=Shi,%20Yuan&rft.date=2015-03-01&rft.volume=358&rft.issue=1&rft.spage=27&rft.epage=36&rft.pages=27-36&rft.issn=0304-3835&rft.eissn=1872-7980&rft_id=info:doi/10.1016/j.canlet.2014.12.014&rft_dat=%3Cproquest_cross%3E1652417369%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652417369&rft_id=info:pmid/25511742&rft_els_id=1_s2_0_S0304383514007575&rfr_iscdi=true |