miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ

Highlights • The expression of REGγ is dysregulated in breast cancer. • The knockdown of REGγ inhibits cancer cell progression in vitro. • REGγ was identified as a downstream target gene of miR-7-5p. • The overexpression of miR-7-5p exerted anti-tumor effects mainly by targeting REGγ in vitro and in...

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Veröffentlicht in:	Cancer letters 2015-03, Vol.358 (1), p.27-36
Hauptverfasser:	Shi, Yuan, Luo, Xinrong, Li, Peng, Tan, Jinxiang, Wang, Xiaoyi, Xiang, Tingxiu, Ren, Guosheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Autoantigens - biosynthesis Autoantigens - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Proliferation - genetics Female Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Hematology, Oncology and Palliative Medicine Humans MCF-7 Cells MicroRNAs - genetics miR-7-5p Proliferation Proteasome Endopeptidase Complex - biosynthesis Proteasome Endopeptidase Complex - genetics REGγ Xenograft Model Antitumor Assays
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Beschreibung
Zusammenfassung:	Highlights • The expression of REGγ is dysregulated in breast cancer. • The knockdown of REGγ inhibits cancer cell progression in vitro. • REGγ was identified as a downstream target gene of miR-7-5p. • The overexpression of miR-7-5p exerted anti-tumor effects mainly by targeting REGγ in vitro and in vivo. • There is an inverse correlation between the expression of REGγ and miR-7-5p.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.12.014