Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

A look at enzymatic fluorination and biotechnological developments of the enzyme fluorinase is presented. Engineering fluorosalinosporamide production in Salinospora tropica and recently identified bacterial fluorinases are among the topics discussed.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical reviews 2015-01, Vol.115 (2), p.634-649
Hauptverfasser: O’Hagan, David, Deng, Hai
Format: Artikel
Sprache:eng
Schlagworte:
Acetyl Coenzyme A - metabolism
Animals
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biosynthesis
Biotechnology
Enzymes
Fluorides
Halogenation
Hydrocarbons, Fluorinated - chemistry
Hydrocarbons, Fluorinated - metabolism
Lactones - chemistry
Lactones - metabolism
Oxidoreductases - chemistry
Oxidoreductases - genetics
Oxidoreductases - metabolism
Positron-Emission Tomography
Protein Engineering
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - metabolism
Skin Neoplasms - diagnosis
Skin Neoplasms - diagnostic imaging
Streptomyces - enzymology
Streptomyces - metabolism
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Beschreibung
Zusammenfassung:A look at enzymatic fluorination and biotechnological developments of the enzyme fluorinase is presented. Engineering fluorosalinosporamide production in Salinospora tropica and recently identified bacterial fluorinases are among the topics discussed.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr500209t