Developing cutaneous applications of paromomycin entrapped in stimuli-sensitive block copolymer nanogel dispersions

A new paromomycin micellar nanogel based on poloxamer 407 was developed. release and permeation/retention studies were conducted. tolerance was assayed by transepidermal water loss. cytotoxicity on RAW and VERO cells and antileishmanial activity on promastigotes was tested. The particle size was 9.19 nm (99% loading efficiency) exhibiting Newtonian behavior at 4°C and was pseudoplastic at 25 and 40°C. Drug release followed a Weibull model and the drug remaining in the skin was 31.652 µg/g/cm . tolerance achieved excellent results with negligible cellular toxicity and the best antileishmanial efficiency. The nanogel provided controlled, effective and safe delivery of paromomycin for the treatment of cutaneous leishmaniasis.