A pre-structured helix in the intrinsically disordered 4EBP1

A pre-structured helix in the intrinsically disordered 4EBP1

The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unst...

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Veröffentlicht in:Molecular bioSystems 2015-02, Vol.11 (2), p.366-369
Hauptverfasser: Kim, Do-Hyoung, Lee, Chewook, Cho, Ye-Jin, Lee, Si-Hyung, Cha, Eun-Ji, Lim, Ji-Eun, Sabo, T Michael, Griesinger, Christian, Lee, Donghan, Han, Kyou-Hoon
Format: Artikel
Sprache:eng
Schlagworte:
Adaptor Proteins, Signal Transducing - chemistry
Humans
Intrinsically Disordered Proteins - chemistry
Magnetic Resonance Spectroscopy
Models, Molecular
Phosphoproteins - chemistry
Protein Structure, Secondary
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Zusammenfassung:The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.
ISSN:1742-206X
1742-2051
DOI:10.1039/c4mb00532e