Predictive value of serum actin-free Gc-globulin for complications and outcome in acute liver failure

Summary This prospective study was designed to evaluate whether early changes in actin‐free Gc‐globulin levels were associated with complications and outcomes and to identify factors associated with persistent low actin‐free Gc‐globulin levels in acute liver failure (ALF). Thirty‐two consecutive ALF patients admitted from October 2011 to December 2012 were followed up until death or complete recovery. All had serum actin‐free Gc‐globulin estimation at admission and at day three or expiry. Logistic regression analysis was performed to identify independent predictors of mortality. A receiver operating characteristic curve analysis was also performed. Nonsurvivors had significantly lower median actin‐free Gc‐globulin levels than survivors (87.32 vs 180 mg/L; P