Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma

Highlights • Use cobalt to create a hypoxic environment with upregulated HIF-1α. • Upregulation of HIF-1α leads to drug resistance and stemness. • Cell stemness can be evaluated by CD166. • CD166-positive cells showed solid drug resistance. • HIF-1α and CD166 may be a biomarker for prognosis in lung...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-02, Vol.87 (2), p.98-106
Hauptverfasser:	Zhao, Mingchuan, Zhang, Yishi, Zhang, Huijun, Wang, Shaohua, Zhang, Mengmeng, Chen, Xi, Wang, Heyong, Zeng, Gang, Chen, Xiaofeng, Liu, Gentao, Zhou, Caicun
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated-Leukocyte Cell Adhesion Molecule - genetics Activated-Leukocyte Cell Adhesion Molecule - metabolism Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma of Lung Adult Aged Aged, 80 and over Antineoplastic Agents - pharmacology Biomarkers Cancer stem cells CD166 Cell Hypoxia - genetics Cell Line, Tumor Dose-Response Relationship, Drug Drug resistance Drug Resistance, Neoplasm - genetics Female Gene Expression Hematology, Oncology and Palliative Medicine Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunophenotyping Lung adenocarcinoma Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Male Middle Aged Neoplasm Grading Neoplasm Staging Neoplastic Stem Cells - metabolism Prognosis Pulmonary/Respiratory RNA, Messenger - genetics RNA, Messenger - metabolism Survival Analysis Young Adult
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Zusammenfassung:	Highlights • Use cobalt to create a hypoxic environment with upregulated HIF-1α. • Upregulation of HIF-1α leads to drug resistance and stemness. • Cell stemness can be evaluated by CD166. • CD166-positive cells showed solid drug resistance. • HIF-1α and CD166 may be a biomarker for prognosis in lung adenocarcinoma.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2014.11.017