Phenindione interference in enzymatic creatinine assay - A case report

Enzymatic creatinine assays are considered superior to Jaffe assays due to greater analytical specificity. We report a case of phenindione interference with an enzymatic assay resulting in significant misclassification in a patient with chronic kidney disease (CKD). Analysis of creatinine values of...

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Veröffentlicht in:	Clinical nephrology 2015-02, Vol.83 (2), p.121-123
Hauptverfasser:	Natarajan, Balan, Hart, Tanya, Smith, Sophy, Parry, Robin Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - administration & dosage Anticoagulants - adverse effects Anticoagulants - blood Creatinine - blood Diagnostic Errors Enzyme Assays - methods Glomerular Filtration Rate Humans Male Middle Aged Phenindione - administration & dosage Phenindione - adverse effects Phenindione - blood Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - physiopathology
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Zusammenfassung:	Enzymatic creatinine assays are considered superior to Jaffe assays due to greater analytical specificity. We report a case of phenindione interference with an enzymatic assay resulting in significant misclassification in a patient with chronic kidney disease (CKD). Analysis of creatinine values of a further 36 patients who were treated with phenindione showed significant negative interference of phenindione with the Roche enzymatic creatinine assay.
ISSN:	0301-0430
DOI:	10.5414/CN108108