Global Resource Distribution: Allocation of Actin Building Blocks by Profilin

Global Resource Distribution: Allocation of Actin Building Blocks by Profilin

How cells regulate the distribution of a limited pool of actin between two competing structures has long been a mystery. Complementary studies from Suarez et al. (2015) and Rotty et al. (2015) now show that profilin controls the partitioning of actin monomers between competing actin networks assembl...

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Veröffentlicht in:Developmental cell 2015-01, Vol.32 (1), p.5-6
Hauptverfasser: Henty-Ridilla, Jessica L., Goode, Bruce L.
Format: Artikel
Sprache:eng
Schlagworte:
Actin Cytoskeleton - metabolism
Actin-Related Protein 2-3 Complex - metabolism
Actins - metabolism
Animals
Female
Homeostasis - physiology
Male
Profilins - metabolism
Schizosaccharomyces - metabolism
Schizosaccharomyces pombe Proteins - metabolism
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Beschreibung
Zusammenfassung:How cells regulate the distribution of a limited pool of actin between two competing structures has long been a mystery. Complementary studies from Suarez et al. (2015) and Rotty et al. (2015) now show that profilin controls the partitioning of actin monomers between competing actin networks assembled by Arp2/3 complex and formins or Ena/VASP.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2014.12.022