The MRE11 complex: An important source of stress relief

•Newly identified interactions with the FHA and BRCT domains of NBS1 influence subcellular localization of the MRE11 complex.•The MRE11 complex promotes TOPBP1 recruitment and ATR activation during replication stress.•The MRE11 complex is a barrier to oncogene-induced tumorigenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Experimental cell research 2014-11, Vol.329 (1), p.162-169
Hauptverfasser:	Rein, Katrin, Stracker, Travis H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Ataxia Telangiectasia Mutated Proteins - metabolism Cancer Carrier Proteins - metabolism Cell cycle checkpoint Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cellular biology DNA damage DNA repair DNA Replication DNA-Binding Proteins - metabolism Genomic instability Genomics Humans MRE11 MRE11 Homologue Protein NBS1 Nuclear Proteins - metabolism Oncology RAD50 Replication fork Stress Tumorigenesis
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Beschreibung
Zusammenfassung:	•Newly identified interactions with the FHA and BRCT domains of NBS1 influence subcellular localization of the MRE11 complex.•The MRE11 complex promotes TOPBP1 recruitment and ATR activation during replication stress.•The MRE11 complex is a barrier to oncogene-induced tumorigenesis.
ISSN:	0014-4827 1090-2422
DOI:	10.1016/j.yexcr.2014.10.010