Maintaining stable memory engrams: New roles for Nogo-A in the CNS

Highlights • Nogo-A interacts with different receptors (NgR1, S1P2R, PirB). • Nogo-A restricts plasticity and growth-dependent processes. • Nogo-A stabilizes neuronal networks. • Taking away these brakes allow the induction of structural/functional rearrangements. • And might promote compensatory gr...

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Veröffentlicht in:	Neuroscience 2014-12, Vol.283, p.17-25
Hauptverfasser:	Zagrebelsky, M, Korte, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System - cytology Central Nervous System - physiology dendrites hippocampus Humans Memory - physiology Myelin Proteins - physiology Nerve Net - physiology Neurology Neuronal Plasticity - physiology Nogo Proteins Nogo-A Signal Transduction - physiology spines structural plasticity synaptic plasticity
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Zusammenfassung:	Highlights • Nogo-A interacts with different receptors (NgR1, S1P2R, PirB). • Nogo-A restricts plasticity and growth-dependent processes. • Nogo-A stabilizes neuronal networks. • Taking away these brakes allow the induction of structural/functional rearrangements. • And might promote compensatory growth processes after an injury of the CNS.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.08.030