Lewis Acid Catalyzed Intramolecular [3 + 2] Cross Cycloadditions of Cobalt-Alkynylcyclopropane 1,1-Diesters with Carbonyls for Construction of Medium-Sized and Polycyclic Skeletons

Lewis Acid Catalyzed Intramolecular [3 + 2] Cross Cycloadditions of Cobalt-Alkynylcyclopropane 1,1-Diesters with Carbonyls for Construction of Medium-Sized and Polycyclic Skeletons

A Lewis acid catalyzed intramolecular [3 + 2] cross cycloaddition of cobalt-alkynylcyclopropane 1,1-diesters with carbonyls has been successfully developed. Together with simple and efficient postcycloadditions of the cobalt-alkyne moiety, a general and efficient strategy for construction of structu...

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Veröffentlicht in:Organic letters 2015-01, Vol.17 (2), p.218-221
Hauptverfasser: Zhang, Junhui, Xing, Siyang, Ren, Jun, Jiang, Shende, Wang, Zhongwen
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Catalysis
Cobalt - chemistry
Cycloaddition Reaction
Cyclopropanes - chemistry
Lewis Acids - chemistry
Molecular Structure
Polycyclic Compounds - chemical synthesis
Polycyclic Compounds - chemistry
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Zusammenfassung:A Lewis acid catalyzed intramolecular [3 + 2] cross cycloaddition of cobalt-alkynylcyclopropane 1,1-diesters with carbonyls has been successfully developed. Together with simple and efficient postcycloadditions of the cobalt-alkyne moiety, a general and efficient strategy for construction of structurally complex and diverse medium-sized skeletons and related polycycles was supplied successfully.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol503285u