General Last-Step Labeling of Biomolecule-Based Substrates by [12C], [13C], and [11C] Carbon Monoxide

General Last-Step Labeling of Biomolecule-Based Substrates by [12C], [13C], and [11C] Carbon Monoxide

Alkaloid-, steroid-, biotin-, carbohydrate-, nucleoside-, and peptide-based bioconjugates are easily labeled with CO by a last-step palladium-catalyzed carbonylation. The choice of the [12C], [13C], or [11C] isotope opens the way to a new class of potential tracers or ligands easily available for va...

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Veröffentlicht in:Organic letters 2015-01, Vol.17 (2), p.354-357
Hauptverfasser: Cornilleau, Thomas, Audrain, Hélène, Guillemet, Aude, Hermange, Philippe, Fouquet, Eric
Format: Artikel
Sprache:eng
Schlagworte:
Carbon Isotopes - chemistry
Carbon Monoxide - chemistry
Carbon Radioisotopes - chemistry
Catalysis
Immunologic Factors - chemistry
Isotope Labeling - methods
Molecular Structure
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Zusammenfassung:Alkaloid-, steroid-, biotin-, carbohydrate-, nucleoside-, and peptide-based bioconjugates are easily labeled with CO by a last-step palladium-catalyzed carbonylation. The choice of the [12C], [13C], or [11C] isotope opens the way to a new class of potential tracers or ligands easily available for various applications.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol503471e